PRESS RELEASE: TASIN Selectively Targets Colon Cancer Cells Expressing Truncated APC
A study conducted at the Departments of Biochemistry (Jef De Brabander) and Cell Biology (Jerry Shay), University of Texas Southwestern Medical Center, Dallas, TX has demonstrated that TASIN (Truncated APC Selective INhibitor), a recently identified small molecule, selectively kills colorectal cancer cells (CRC) by inducing endoplasmic reticulum (ER) stress which leads to activation of the pro-apoptotic JNK pathway and PARP cleavage.